CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing
نویسندگان
چکیده
Sangwook Choi, Sara M. Camp, Arkaprava Dan, Joe G. N. Garcia, Steven M. Dudek, and Deborah E. Leckband Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois; Department of Medicine, University of Arizona, Tucson, Arizona; Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois Hospital and Health Sciences System, Chicago, Illinois; and Department of Chemistry, University of Illinois, Urbana, Illinois
منابع مشابه
A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing.
Inflammatory mediators released in acute lung injury (ALI) trigger the disruption of interendothelial junctions, leading to loss of vascular barrier function, protein-rich pulmonary edema, and severe hypoxemia. Genetic signatures that predict patient recovery or disease progression are poorly defined, but recent genetic screening of ALI patients has identified an association between lung inflam...
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